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Gabapentin (brand name: Neurontin®) is an anticonvulsant medication indicated in the treatment of epilepsy and neuropathic pain. Gabapentin is known for having a relatively mild side effect profile, and passes through the body unmetabolized.
Gabapentin is similar in structure to the neurotransmitter GABA but is not believed to act on the same brain receptors. Its exact mechanism of action is unknown, but its therapeutic action on neuropathic pain is thought to involve voltage gated calcium ion channels.
Gabapentin has also been used in the treatment of bipolar disorder. However the FDA has never approved gabapentin for the treatment of bipolar disorder, and its use for this purpose is increasingly controversial. Some claim gabapentin acts as a mood stabilizer and has the advantage of having fewer side effects than more conventional bipolar drugs such as lithium and depakote. Some small, non-controlled studies in the 1990s, most sponsored by gabapentin's manufacturer, suggested that gabapentin treatment for bipolar disorder may be promising. However, more recently, several larger, controlled, and double-blind studies have found that gabapentin was no more effective than (and in one study, slightly less effective than) placebo, and the manufacturer has even halted its own studies regarding gabapentin and bipolar disorder. Despite this scientific evidence against the efficacy of gabapentin in the treatment of bipolar disorder, many psychiatrists continue to prescribe it for this purpose.
Gabapentin has also been used (also without FDA approval) in the treatment of anxiety disorders such as social anxiety disorder and obsessive-compulsive disorder, in treatment-resistant depression, and for insomnia. Gabapentin may be effective in reducing pain and spasticity in multiple sclerosis. In addition to its use in mood disorders, gabapentin was approved by the FDA for treating postherpetic neuralgia (neuropathic pain following shingles).
Gabapentin is best known under the brand name Neurontin manufactured by Pfizer . In October 2004, FDA approved a generic equivalent to Neurontin made by Israeli firm Teva. Neurontin is one of Pfizer's best selling drugs, and was one of the 50 most prescribed drugs in the United States in 2003. However, in recent years Pfizer has come under heavy criticism for its marketing of Neurontin, facing allegations that behind the scenes Pfizer marketed the drug for at least a dozen supposed uses for which the drug had not been FDA approved. By some estimates, so-called "off-label" prescriptions account for roughly 90% of Neurontin sales. While off-label prescriptions are common for a number of drugs and are perfectly legal (if not always appropriate), marketing for off label uses of a drug is strictly illegal. In 2004, Pfizer agreed to pay a $430 million settlement for the illegal marketing of Neurontin for off-label purposes, and further legal action is pending.
Pfizer is developing a successor to gabapentin, called pregabalin, which Pfzier hopes will be approved for use in epilepsy and neuropathic pain, as well as some of gabapentin's off label uses, especially anxiety disorders.
Gabapentin's main side effect is drowsiness. Fortunately, in most cases, the drowsiness subsides after a few days, but the therapeutic effects persist.
(this article compliments of Wikipedia)
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Neurontin News
Teva Receives First U.S. Approval For Generic Risperdal(R) Tablets; Commences Commercial Launch (Medical News Today) Teva Pharmaceutical Industries Ltd. (NASDAQ:TEVA) announced that the U.S. Food and Drug Administration has granted final approval for the Company's Abbreviated New Drug Application (ANDA) to market its generic version of Janssen's antipsychotic agent Risperdal® (Risperidone) Tablets, 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg. Shipment of these products has commenced. | Teva Provides Update on Generic Seroquel(R) Litigation (Centre Daily Times) Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA) announced today that the U.S. District Court for the District of New Jersey has issued a decision in its litigation over the Company's Abbreviated New Drug Application (ANDA) to market its generic version of AstraZeneca's Seroquel(R) (Quetiapine) Tablets. The Court granted summary judgment in AstraZeneca's favor on the issue of no inequitable ... | Teva Provides Update on Generic Seroquel(R) Litigation (Business Wire via Yahoo! Finance) JERUSALEM----Teva Pharmaceutical Industries Ltd. announced today that the U.S. District Court for the District of New Jersey has issued a decision in its litigation over the Company's Abbreviated New Drug Application to market its generic version of AstraZeneca's Seroquel® Tablets. | The medicine cabinet: Treating fibromyalgia (Newsday) What is the best and safest painkiller I can use long term for fibromyalgia? I suffer from severe headaches, muscle and joint pain, as well as back pain. | Teva Receives First U.S. Approval for Generic Risperdal(R) Tablets; Commences Commercial Launch (Centre Daily Times) Teva Pharmaceutical Industries Ltd. (NASDAQ:TEVA) announced today that the U.S. Food and Drug Administration has granted final approval for the Company's Abbreviated New Drug Application (ANDA) to market its generic version of Janssen's antipsychotic agent Risperdal(R) (Risperidone) Tablets, 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg. Shipment of these products has commenced. |

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