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Side-effects of Accutane

The most feared complication of isotretinoin is its teratogenicity, i.e., the ability to cause birth defects. Isotretinoin has many side effects, listed in the table on the right. The more severe side effects are listed here in more detail.

It is also worth noting that the following side effects can persist, even after discontinuing therapy:

  • Alopecia (hair loss)
  • Arthralgias
  • Decreased night vision
  • Degenerative Disc Disease
  • Cartilage Degeneration
  • Bone disease

It should also be mentioned that isotretinoin users are not allowed to give blood for at least a month after having discontinued isotretinoin use.

Teratogenicity

Isotretinoin is a teratogen - it is highly likely that if taken during pregnancy that it will cause birth defects. In the USA, isotretinoin is in pregnancy category X. Isotretinoin must be prescribed under a policy that mandates that female patients be placed on two separate, effective forms of birth control [3]. Male patients should be informed of the risk associated with use during pregnancy, emphasising that they should not share the drug, especially with females.

In the U.S. more than 2,000 women have become pregnant while taking the drug between 1982 and 2003, with most pregnancies ending in abortion. About 160 babies with birth defects were born. Doctors normally require two separate methods of birth control for sexually active women taking isotretinoin and until one month after terminating the drug.

Depression

Several studies [4][5][6] have emerged suggesting a possible link between isotretinoin and depression. It must however be acknowledged that its primary use is for the treatment of the most severe acne. The possibility that this severe acne is causing the depression is therefore not to be ruled out. Moreover, improvement of a patient's acne by successful treatment with isotretinoin can actually reduce symptoms of anxiety and depression. [7] Statistical evidence shows that the suicide rate among Accutane users is actually lower than average. [8]

Emory University conducted a study of isotretinoin and depression. The study subjects were given psychological tests beforehand that showed no correlation between the severity of their acne and feelings of depression. A baseline PET scan of all the subjects was done. A second PET scan showed that individuals who had used the drug for four months showed decreased activity in the orbitofrontal cortex, a section of the brain thought to control mood and social interaction. Individuals in the control group who had not used the drug showed no change. (Bremner et al. 2005)

Alleged cases of isotretinoin linked suicide

After Charles Bishop, a 15-year old student pilot, flew a light aircraft into a Tampa, Florida building on January 5, 2002, his family claimed Accutane had caused severe psychosis in the boy and filed a $70 million lawsuit against Hoffman-La Roche. However, an autopsy found no traces of the drug in the boy's system.

Bart Stupak, a Michigan congressman, has alleged this connection ever since his son, B.J., an Accutane user, committed suicide hours after his junior prom in May 2000. (this article compliements of Wikipedia)

Acctane Resources

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Our goal with the Accutane section of LawyerFinder.com is to try and help legal consumers get in touch with legal professionals practicing Accutane law, such as: Accutane lawyers, Accutane law firm or Accutane attorneys.

Accutane News

VIDEO: She gets to be a kid for once (The Examiner)
Thanks to study-drug, Accutane, 2-year-old Bailey Bennett of Independence and her family are hoping that her life-threatening illness will be in remission this month.

Breakout solutions help adults with acne (Orlando Sentinel)
Acne isn't a problem that magically disappears when you turn 20. Even though it's thought of as a teen skin problem, many adults -- in fact, most adults -- have at least occasional outbreaks of acne.

What women should know about fertility (The Herald News)
What women should know

Last Minute Drug Approvals Linked to Postmarket Safety Issues (Psychiatric Times)
Drugs approved by the FDA just before mandated deadlines are more likely to have safety issues after entering the market than those approved at other times, according to a study in the March 27 New England Journal of Medicine . 1 Coincidentally, on that date, the FDA announced the first group of marketed medications, including the atypical antipsychotic clozapine (Clozaril), for which it is ...

Hope, in a time of horror for pregnant cancer patients (Miami Herald)
Something felt wrong in Leila Sadat's right breast. The Washington University law professor tried to ignore the nagging worry about a hard spot that mammograms did not detect. Doctors thought it was nothing more serious than a blocked milk duct. It couldn't be cancer. Sadat was pregnant.


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